Thionyl Chloride → HCID 20368183, 화합물

HRID 268309노트

반응식

HRID 268309 반응식
P(Cl)(Cl)Cl.P(Br)(Br)Br.P(F)(F)F.S(Cl)([Cl:15])=O.[NH2:17][C:18]1[N:22]([CH2:23][CH2:24]O)[N:21]=[C:20]([C:26]2[N:27]([CH3:34])[C:28]([N+:31]([O-:33])=[O:32])=[CH:29][N:30]=2)[C:19]=1[C:35]#[N:36]>CN(C)C=O.C1C=CC=CC=1>[NH2:17][C:18]1[N:22]([CH2:23][CH2:24][Cl:15])[N:21]=[C:20]([C:26]2[N:27]([CH3:34])[C:28]([N+:31]([O-:33])=[O:32])=[CH:29][N:30]=2)[C:19]=1[C:35]#[N:36]

참가 물질

8

반응물 5

HCID 24386Thionyl Chloride2회HCID 24387Phosphorus trichlorideHCID 24614Phosphorus tribromideHCID 62665Phosphorus trifluorideHCID 20368169HCID 20368169, 화합물

생성물 1

HCID 20368183HCID 20368183, 화합물

시약·촉매·용매 2

HCID 241Benzene용매HCID 6228Dimethylformamide용매

실험 절차

The preparation of a 5-amino-1-(haloalkyl)-3-(1-methyl-5-nitro-2-imidazolyl)pyrazole-4-carbonitrile is accomplished by reacting the corresponding hydroxy-alkyl compound with a halogenating agent such as phosphorus trichloride, phosphorus tribromide, phosphorus trifluoride, thionyl chloride and the like. Thus, 5-amino-1-(β-hydroxyethyl)-3-(1-methyl-5-nitro-2-imidazolyl)pyrazole-4-carbonitrile, is allowed to react with thionyl chloride in an inert solvent, such as benzene, in the presence of a small amount of dimethyl-formamide to yield 5-amino-1-(β-chloroethyl)-3-(1-methyl-5-nitro-2-imidazolyl)pyrazole-4-carbonitrile.

출처 및 근거

ORD 기록
ord-1299efd732fa4175a0c4621f83e86606
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03947467

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