L-(+)-Cysteine → Isopenicillin N
반응식
CC1(C)[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([CH2:13][C:14]3C=CC=CC=3)=[O:12])[C:8](=[O:9])N2[C@H]1C([O-])=O.[K+].[NH2:25][C@H:26]([C:29]([OH:31])=[O:30])[CH2:27]S.[NH2:32][C@H:33]([C:37]([OH:39])=[O:38])[CH:34]([CH3:36])[CH3:35]>>[CH3:35][C:34]1([CH3:36])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([CH2:13][CH2:14][CH2:27][C@H:26]([NH2:25])[C:29]([OH:31])=[O:30])=[O:12])[C:8](=[O:9])[N:32]2[C@H:33]1[C:37]([OH:39])=[O:38]참가 물질
4
실험 절차
The first two steps in the biosynthesis of penicillin in P. chrysogenum are the condensation of the three amino acids L-5-amino-5-carboxypentanoic acid (L-α-aminoadipic acid) (A), L-cysteine (C) and L-valine (V) into the tripeptide LLD-ACV, followed by cyclization of this tripeptide to form isopenicillin N. This compound contains the typical β-lactam structure.
출처 및 근거
- ORD 기록
- ord-2c4f86a4ef96422c818776439d737e2a
- 출처 데이터셋
- uspto-grants-1998_03
- DOI