Purine → Nebularine

HRID 268513

반응식

HRID 268513 반응식
[N:1]1[CH:9]=[C:8]2[C:4]([N:5]=[CH:6][NH:7]2)=[N:3][CH:2]=1.Cl[C@:11]1(CO)[O:16][C:14]([C:17](=[O:19])C)(O)[C@:13](C(=O)C)([OH:20])[C@:12]1(C(=O)C)[OH:24].CO.N>C(Cl)(Cl)Cl>[CH:9]1[C:8]2[N:7]=[CH:6][N:5]([C@@H:11]3[O:16][C@H:14]([CH2:17][OH:19])[C@@H:13]([OH:20])[C@H:12]3[OH:24])[C:4]=2[N:3]=[CH:2][N:1]=1

참가 물질

5

반응물 3

HCID 1044Purine2회HCID 21705897Ammonia methanolHCID 131710119Chlorotriacetylribofuranose

생성물 1

HCID 68368Nebularine

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Nebularine was prepared by the use of the thallous salt of purine in the procedure of Brown et al., J. Biol. Chem. 204, 1019 (1953), in place of the chloromercuri salt used therein. The thallous salt of purine is condensed with chlorotriacetylribofuranose and the resulting acetyl derivative hydrolyzed to the product with methanol-ammonia. Other experimental conditions were identical. Crystalline nebularine was obtained after chromatography of the crude product on silica-gel with chloroform.

출처 및 근거

ORD 기록
ord-b9a10572cee545b7be20058119fe82e0
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03947488

연결된 노트

불러오는 중…