Hydrochloric Acid → 5,7-Dimethylindole

HRID 268676노트

반응식

HRID 268676 반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH3:11])[CH:10]=1)[NH:7][C:6](=O)[C:5]2=O.Cl.C(=O)(O)[O-].[Na+]>O1CCCC1>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH3:11])[CH:10]=1)[NH:7][CH:6]=[CH:5]2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 382965,7-dimethyl-2,3-dihydro-1H-indole-2,3-dioneHCID 516892Sodium Bicarbonate

생성물 1

HCID 5893955,7-Dimethylindole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To solution of 5,7-dimethyl-1H-indole-2,3-dione in tetrahydrofuran at 0° C. was added 1.0 M solution of borane-tetrahydrofuran complex in tetrahydrofuran (40 mL). After stirred at room temperature overnight, a 5% HCl solution was added to the mixture and it was stirred 20 minutes. It was neutralized with saturated sodium bicarbonate solution and extracted with ethyl acetate. Extracts were dried over magnesium sulfate and evaporated to dryness to afford the title compound as oil.

후처리

  1. stirringwas stirred 20 minutes
  2. extractionextracted with ethyl acetate
  3. dry with materialExtracts were dried over magnesium sulfate
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-df40a1c683f744a0950f484c0ecc2580
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446122B2

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