4-(3-Piperidin-1-ylpropoxy)benzoic acid hydrochloride → 4-(3-Piperidin-1-ylpropoxy)benzoyl chloride hydrochloride

HRID 268707

반응식

HRID 268707 반응식
[ClH:1].[N:2]1([CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:20]=[CH:19][C:15]([C:16](O)=[O:17])=[CH:14][CH:13]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1>S(Cl)(Cl)=O>[ClH:1].[N:2]1([CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([Cl:1])=[O:17])=[CH:14][CH:13]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

3

반응물 1

HCID 689636144-(3-Piperidin-1-ylpropoxy)benzoic acid hydrochloride

생성물 1

HCID 218520624-(3-Piperidin-1-ylpropoxy)benzoyl chloride hydrochloride수율 196.6%

시약·촉매·용매 1

HCID 24386Thionyl Chloride용매

실험 절차

4-(3-Piperidin-1-ylpropoxy)benzoic acid hydrochloride (D2) (0.23 g) in thionyl chloride (5 ml) was heated under reflux for 1 h. The reaction mixture was then evaporated to a minimum and co-evaporated from DCM (3×10 ml) to give the title compound (D3) as a white powder (0.24 g).

후처리

  1. temperatureunder reflux for 1 h
  2. customThe reaction mixture was then evaporated to a minimum

출처 및 근거

ORD 기록
ord-67c8ebd31205405786cdabfc6fd90b85
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446103B2

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