Hydrochloric Acid → 2-Chloro-4-(piperidin-4-yloxy)-benzonitrile hydrochloride

HRID 268724노트

반응식

HRID 268724 반응식
[Cl:1][C:2]1[CH:9]=[C:8]([O:10][CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].Cl>CO.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:9]=[C:8]([O:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 17986305HCID 17986305, 화합물

생성물 1

HCID 179862902-Chloro-4-(piperidin-4-yloxy)-benzonitrile hydrochloride

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

2-Chloro-4-[(1-tert-butoxycarbonyl-4-piperidinyl)oxy]benzonitrile (D29) (5.0 g) was dissolved in methanol (150 ml) and 4N HCl in dioxane (100 ml) was added. The reaction stirred at rt overnight. The reaction mixture was then evaporated to give the title compound (D30) as a white solid (4.0 g).

후처리

  1. customThe reaction mixture was then evaporated

출처 및 근거

ORD 기록
ord-5f60f505214a4d989575c79bb5cceb03
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446103B2

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