2-Amino-2-methyl-1-propanol → 5-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-2-methoxybenzenesulfonamide

HRID 268932노트

반응식

HRID 268932 반응식
[NH2:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].[Br:7][C:8]1[CH:9]=[CH:10][C:11]([O:18][CH3:19])=[C:12]([S:14](Cl)(=[O:16])=[O:15])[CH:13]=1>>[Br:7][C:8]1[CH:9]=[CH:10][C:11]([O:18][CH3:19])=[C:12]([S:14]([NH:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4])(=[O:15])=[O:16])[CH:13]=1

참가 물질

3

반응물 2

HCID 118072-Amino-2-methyl-1-propanolHCID 5200205-Bromo-2-methoxybenzene-1-sulfonyl chloride

생성물 1

HCID 275180375-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-2-methoxybenzenesulfonamide수율 99.3%

실험 절차

Prepared by general procedure III from 2-amino-2-methyl-1-propanol (2.23 g, 25 mmol) and commercially available 5-bromo-2methoxybenzenesulfonyl chloride (1.43 g, 5 mmol) to give the title compound as an off-white solid (1.68 g, 99%). MS (ISN) 336.2 [(M−H)−], 338.1 [(M+2−H)−]. mp 168° C.

출처 및 근거

ORD 기록
ord-670d63bd68e34e5c85ccf7373b2272f6
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446113B2

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