Sodium Iodide → 5-Iodo-3-(trifluoromethyl)pyridin-2-amine
반응식
Br[C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[C:5]([NH2:8])=[N:6][CH:7]=1.[I-:13].[Na+]>C(O)CCC.[Cu]I.CNCCNC>[I:13][C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[C:5]([NH2:8])=[N:6][CH:7]=1참가 물질
6
반응 조건
- 온도
- 23 °C
실험 절차
A mixture of 5-bromo-3-trifluoromethyl-pyridin-2-ylamine (example C.18 step 3) (723 mg, 3 mmol), sodium iodide (900 mg, 6 mmol), copper (I) iodide (29 mg, 5 mol %) and N,N′-dimethylethylendiamine (26 mg, 10 mol %) in n-butanol (6 mL) was stirred at reflux under argon atmosphere for 18 h. The reaction mixture was cooled to 23° C., extracted with ethyl acetate and water, the organic layers were dried over MgSO4, filtered and evaporated to leave the title compound as a brown solid (880 mg, 102%), which was used without further purification. MS (ISN) 287.0 [(M−H)−].
후처리
- temperatureat reflux under argon atmosphere for 18 h
- extractionextracted with ethyl acetate and water
- dry with materialthe organic layers were dried over MgSO4
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-a774a02f03634853adede33f69fc3246
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07446113B2
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