Acetyl chloride → HCID 68947033, 화합물

HRID 269439노트

반응식

HRID 269439 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[C:5](Cl)(=[O:7])[CH3:6].[CH2:9]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]>ClCCl>[C:5]([CH:12]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:11][CH2:10][CH2:9][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)(=[O:7])[CH3:6]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 16476PentadecylbenzeneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 68947033HCID 68947033, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

A 500-ml-three-necked round-bottomed flask, with an efficient cooling was charged with aluminium chloride (5.82 g, 43.67 mmol) and dichloromethane (100 ml). Acetyl chloride (3.42 g, 43.67 mmol) was added to the vigorously stirred reaction mixture over a period of 15 minutes. Pentadecyl benzene (10 g, 34.66 mmol) was added over a period of 30 minutes; the clear solution was stirred at 0° C. for 2 hours and allowed to warm to room temperature. The reaction mixture was poured in ice and extracted with dichloromethane (3×100 ml), the combined organic layers was washed with 1 N hydrochloric acid (2×30 ml) and water (3×50 ml), dried over sodium sulfate and the solvent was evaporated to obtain 4-acetyl pentadecyl benzene as a low melting faint yellow solid. The yield was 10 g (87% of theoretical).

후처리

  1. temperatureA 500-ml-three-necked round-bottomed flask, with an efficient cooling
  2. temperatureto warm to room temperature
  3. additionThe reaction mixture was poured in ice
  4. extractionextracted with dichloromethane (3×100 ml)
  5. washthe combined organic layers was washed with 1 N hydrochloric acid (2×30 ml) and water (3×50 ml)
  6. dry with materialdried over sodium sulfate
  7. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-abea354b382545379932525665d4a8a5
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446234B2

반응 노트

불러오는 중…