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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Trifluoroacetic acid → N-(4-{3-[4-(2,3-Difluoro-phenyl)-isoxazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-cyclohex-3-enyl)-methanesulfonamide

HRID 269507
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인쇄 미리보기

반응식

HRID 269507 반응식
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[N:11][O:12][C:13]=1[C:14]1[C:22]2[C:17](=[N:18][CH:19]=[C:20]([C:23]3[CH2:28][CH2:27][CH:26]([NH2:29])[CH2:25][CH:24]=3)[CH:21]=2)[NH:16][CH:15]=1.N1([O:39][S:40]([CH3:43])(=O)=[O:41])C2C=CC=CC=2N=N1.C(O)(C(F)(F)F)=O>CN(C=O)C.CCN(C(C)C)C(C)C>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[N:11][O:12][C:13]=1[C:14]1[C:22]2[C:17](=[N:18][CH:19]=[C:20]([C:23]3[CH2:28][CH2:27][CH:26]([NH:29][S:40]([CH3:43])(=[O:41])=[O:39])[CH2:25][CH:24]=3)[CH:21]=2)[NH:16][CH:15]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 6422Trifluoroacetic acidHCID 11745953Methanesulfonic acid, 1H-benzotriazol-1-yl esterHCID 1354403634-{3-[4-(2,3-difluoro-phenyl)-isoxazol-5-yl]-1H-pyrrolo [2,3-b]pyridin-5-yl}-cyclohex-3-enylamine

생성물 1

HCID 135451017N-(4-{3-[4-(2,3-Difluoro-phenyl)-isoxazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-cyclohex-3-enyl)-methanesulfonamide수율 46%

시약·촉매·용매 2

HCID 81531
Diisopropylethylamine
촉매
HCID 6228Dimethylformamide용매

실험 절차

To a solution of 4-{3-[4-(2,3-Difluoro-phenyl)-isoxazol-5-yl]-1H-pyrrolo [2,3-b]pyridin-5-yl}-cyclohex-3-enylamine (47 mg, 0.12 mmol) in DMF (2 ml) was added methanesulfonic acid benzotriazol-1-yl ester (27 mg, 0.13 mmol) and Hunig base (10 drops) and stirred for 1 h. TFA was added, and the reaction mixture was purified by HPLC to give the methanesulfonamide (25.9 mg) in 46% yield.

후처리

  1. customthe reaction mixture was purified by HPLC

출처 및 근거

ORD 기록
ord-c5adc629554448f4ad58459475edbddd
출처 데이터셋
uspto-grants-2008_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07446199B2

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