Water → 2-Benzyloxy-[1,1';2',1'']terphenyl-3''-carboxylic acid

HRID 269538

반응식

HRID 269538 반응식
C([O:3][C:4]([C:6]1[CH:7]=[C:8]([C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:9]=[CH:10][CH:11]=1)=[O:5])C.[OH-].[Na+].O>C(O)C>[CH2:25]([O:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:13]1[C:12]([C:8]2[CH:9]=[CH:10][CH:11]=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=2)=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 587309952-Benzyloxy-[1,1';2',1'']terphenyl-3''-carboxylic acid ethyl ester

생성물 1

HCID 103623772-Benzyloxy-[1,1';2',1'']terphenyl-3''-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

2-Benzyloxy-[1,1′;2′,1″]terphenyl-3″-carboxylic acid ethyl ester (84 mg, 0.206 mmol) was dissolved in ethanol (2 ml) and 2M sodium hydroxide (0.5 ml) added. The mixture was stirred and heated to 50° C. for 4 h. Water was added and the mixture extracted with isohexane. The aqueous layer was acidified with 2M hydrochloric acid and extracted with diethyl ether (2×10 ml). The combined organic phases were washed with water, dried (MgSO4) and evaporated. The oil was triturated with isohexane and the resulting white solid filtered, washed with isohexane and dried in vacuo. (42 mg, 54%).

후처리

  1. extractionthe mixture extracted with isohexane
  2. extractionextracted with diethyl ether (2×10 ml)
  3. washThe combined organic phases were washed with water
  4. dry with materialdried (MgSO4)
  5. customevaporated
  6. customThe oil was triturated with isohexane
  7. filtrationthe resulting white solid filtered
  8. washwashed with isohexane
  9. customdried in vacuo

출처 및 근거

ORD 기록
ord-d92563337723441e9c318ae746aa1691
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446222B2

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