Sodium hydride → Ethyl 3-bromo-5-(2-oxo-1-pyrrolidinyl)benzoate

HRID 269561노트

반응식

HRID 269561 반응식
[H-].[Na+].[Br:3][C:4]1[CH:5]=[C:6]([CH:12]=[C:13]([NH:15][C:16](=[O:21])[CH2:17][CH2:18][CH2:19]Cl)[CH:14]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8]>C1COCC1>[Br:3][C:4]1[CH:5]=[C:6]([CH:12]=[C:13]([N:15]2[CH2:19][CH2:18][CH2:17][C:16]2=[O:21])[CH:14]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8]

참가 물질

4

반응물 2

HCID 24758Sodium hydrideHCID 69312186Ethyl 3-bromo-5-[(4-chlorobutanoyl)amino]benzoate

생성물 1

HCID 69310922Ethyl 3-bromo-5-(2-oxo-1-pyrrolidinyl)benzoate수율 82%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Sodium hydride, 60% suspension in oil (186 mg, 4.65 mmol) was added portionwise over 2 mins to a solution of ethyl 3-bromo-5-[(4-chlorobutanoyl)amino]benzoate (1.35 g, 3.87 mmol) in dry THF (50 ml) under nitrogen. The reaction mixture was stirred at room temperature for 2 hours. The reaction was quenched by the careful addition of water (25 ml). Diethyl ether (50 ml) was added. The organic phase was washed with water, dried and evaporated to give the title compound as a yellow solid (990 mg, 82%).

후처리

  1. customThe reaction was quenched by the careful addition of water (25 ml)
  2. additionDiethyl ether (50 ml) was added
  3. washThe organic phase was washed with water
  4. customdried
  5. customevaporated

출처 및 근거

ORD 기록
ord-9e48a4e796894b0e8085b0dec450e126
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446222B2

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