Hydrochloric Acid → 2(S)-Amino-3-(2-benzyloxy-5-iodophenyl)propionic acid hydrochloride

HRID 269599노트

반응식

HRID 269599 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([I:15])=[CH:11][C:10]=1[CH2:16][C@H:17]([NH:21]C(OC(C)(C)C)=O)[C:18]([OH:20])=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:29]>O1CCOCC1>[ClH:29].[NH2:21][C@@H:17]([CH2:16][C:10]1[CH:11]=[C:12]([I:15])[CH:13]=[CH:14][C:9]=1[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:18]([OH:20])=[O:19]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 587541472-(benzyloxy)-N-(tert-butoxycarbonyl)-5-iodo-L-phenylalanine

생성물 1

HCID 574636092(S)-Amino-3-(2-benzyloxy-5-iodophenyl)propionic acid hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

12 g (24.13 mmol) of 3-(2-benzyloxy-5-iodophenyl)-2(S)-tert-butoxycarbonylaminopropionic acid (Example (−)-6A) are added under argon into 60 ml of a 4M solution of hydrogen chloride in dioxane and stirred at RT for 2 h. The reaction solution is concentrated and dried under high vacuum.

후처리

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum

출처 및 근거

ORD 기록
ord-f2bad4cca80741709dac5cd6b713c539
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446102B2

반응 노트

불러오는 중…