Diisopropylethylamine → HCID 178454188, 화합물

HRID 269628노트

반응식

HRID 269628 반응식
CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(CC)C(C)C)(C)C.[CH2:34]([O:41][C:42]([NH:44][C:45](=[NH:62])[NH:46][CH2:47][CH2:48][CH2:49][C@@H:50]([C:59]([OH:61])=O)[NH:51][C:52]([O:54][C:55]([CH3:58])([CH3:57])[CH3:56])=[O:53])=[O:43])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.Cl.[NH2:64][CH2:65][CH2:66][NH:67][C:68](=[O:77])[O:69][CH2:70][C:71]1[CH:76]=[CH:75][CH:74]=[CH:73][CH:72]=1>CN(C=O)C>[CH2:70]([O:69][C:68](=[O:77])[NH:67][CH2:66][CH2:65][NH:64][C:59](=[O:61])[C@H:50]([CH2:49][CH2:48][CH2:47][NH:46][C:45]([NH:44][C:42]([O:41][CH2:34][C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1)=[O:43])=[NH:62])[NH:51][C:52]([O:54][C:55]([CH3:56])([CH3:57])[CH3:58])=[O:53])[C:71]1[CH:76]=[CH:75][CH:74]=[CH:73][CH:72]=1

참가 물질

6

반응물 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 12715871Benzyl N-(2-aminoethyl)carbamate hydrochlorideHCID 178454189HCID 178454189, 화합물

생성물 1

HCID 178454188HCID 178454188, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

419.3 mg (1.1 mmol) of HATU and 258.5 mg (2 mmol) of N,N-diisopropylethylamine are added to a solution of 408.4 mg (1 mmol) of N5-[{[(benzyloxy)carbonyl]amino}(imino)methyl]-N2-(tert-butoxycarbonyl)-L-ornithine in 15 ml of anhydrous DMF. After stirring at RT for 15 min, 253.76 mg (1.1 mmol) of benzyl (2-aminoethyl)carbamate hydrochloride are added. The reaction mixture is stirred at RT for 15 h. The solvent is then evaporated and the residue is taken up in dichloromethane. The organic phase is washed with water, dried over magnesium sulfate and concentrated. The crude product is purified by preparative HPLC.

후처리

  1. stirringThe reaction mixture is stirred at RT for 15 h
  2. customThe solvent is then evaporated
  3. washThe organic phase is washed with water
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated
  6. customThe crude product is purified by preparative HPLC

출처 및 근거

ORD 기록
ord-ec7a7be79b97436e8f1719310fd2847e
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446102B2

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