Hydrochloric Acid → HCID 178479349, 화합물

HRID 269629노트

반응식

HRID 269629 반응식
[CH2:1]([O:8][C:9](=[O:42])[NH:10][CH2:11][CH2:12][NH:13][C:14](=[O:41])[C@H:15]([CH2:24][CH2:25][CH2:26][NH:27][C:28]([NH:30][C:31]([O:33]CC1C=CC=CC=1)=[O:32])=[NH:29])[NH:16]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:43]>O1CCOCC1>[ClH:43].[CH2:1]([N:30]([C:28](=[NH:29])[NH:27][CH2:26][CH2:25][CH2:24][C@H:15]([NH2:16])[C:14](=[O:41])[NH:13][CH2:12][CH2:11][NH:10][C:9](=[O:42])[O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:31](=[O:32])[OH:33])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 178454188HCID 178454188, 화합물

생성물 1

HCID 178479349HCID 178479349, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 334 mg (0.417 mmol) of benzyl (2-{[N5-[{[(benzyloxy)carbonyl]amino}(imino)methyl]-N2-(tert-butoxycarbonyl)-L-ornithyl]amino}ethyl)carbamate (Example 102A) and 17 ml of a 4M solution of hydrogen chloride in dioxane is stirred at RT for 4 h. The reaction solution is concentrated, coevaporated with dichloromethane several times, and dried under high vacuum. The crude product is reacted without further purification.

후처리

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

출처 및 근거

ORD 기록
ord-3ff67b89f62c45d486058ea0410e3575
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446102B2

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