Hydrochloric Acid → benzyl((1S)-4-amino-1-{2-[(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-oxoethyl}butyl)carbamate hydrochloride

HRID 269631노트

반응식

HRID 269631 반응식
[ClH:1].[CH2:2]([O:9][C:10](=[O:41])[NH:11][CH2:12][CH2:13][NH:14][C:15](=[O:40])[CH2:16][C@@H:17]([NH:29][C:30]([O:32]CC1C=CC=CC=1)=[O:31])[CH2:18][CH2:19][CH2:20][NH:21]C(OC(C)(C)C)=O)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCOCC1>[ClH:1].[CH2:2]([N:29]([C@H:17]([CH2:16][C:15]([NH:14][CH2:13][CH2:12][NH:11][C:10]([O:9][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)=[O:41])=[O:40])[CH2:18][CH2:19][CH2:20][NH2:21])[C:30](=[O:31])[OH:32])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86624500HCID 86624500, 화합물

생성물 1

HCID 69216382benzyl((1S)-4-amino-1-{2-[(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-oxoethyl}butyl)carbamate hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

8 ml of a 4M solution of hydrogen chloride in dioxane are added to a solution of 320 mg (0.287 mmol) of benzyl[2-({(3S)-3-{[(benzyloxy)carbonyl]amino}-6-[(tert-butoxycarbonyl)amino]hexanoyl}amino)ethyl]carbamate (Example 104A) in 2 ml of dioxane at 0° C. After 1 h at RT, the reaction solution is concentrated in vacuo, coevaporated with dichloromethane several times and dried under high vacuum. The crude product is reacted without further purification.

후처리

  1. concentrationthe reaction solution is concentrated in vacuo
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

출처 및 근거

ORD 기록
ord-16282749c19d4fb582becedfe43dd038
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446102B2

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