Hydrochloric Acid → HCID 69216959, 화합물

HRID 269633노트

반응식

HRID 269633 반응식
[ClH:1].[CH2:2]([O:9][C:10](=[O:59])[NH:11][CH2:12][CH2:13][NH:14][C:15](=[O:58])[CH2:16][C@@H:17]([NH:47][C:48]([O:50][CH2:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1)=[O:49])[CH2:18][CH2:19][CH2:20][NH:21][C:22](=[O:46])[C@H:23]([CH2:32][CH2:33][CH2:34][NH:35][C:36]([O:38]CC1C=CC=CC=1)=[O:37])[NH:24]C(OC(C)(C)C)=O)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCOCC1>[ClH:1].[CH2:2]([N:35]([CH2:34][CH2:33][CH2:32][C@H:23]([NH2:24])[C:22](=[O:46])[NH:21][CH2:20][CH2:19][CH2:18][C@H:17]([NH:47][C:48]([O:50][CH2:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1)=[O:49])[CH2:16][C:15](=[O:58])[NH:14][CH2:13][CH2:12][NH:11][C:10](=[O:59])[O:9][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[C:36](=[O:37])[OH:38])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86624503Benzyl {2-[((3S)-3-{[(benzyloxy)carbonyl]amino}-6-{[N5-[(benzyloxy)carbonyl]-N2-(tert-butoxycarbonyl)-L-ornithyl]amino}hexanoyl)amino]ethyl}carbamate

생성물 1

HCID 69216959HCID 69216959, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

2.5 ml of a 4M solution of hydrogen chloride in dioxane are added to a solution of 48 mg (0.060 mmol) of benzyl{2-[((3S)-3-{[(benzyloxy)carbonyl]amino}-6-{[N5-[(benzyloxy)carbonyl]-N2-(tert-butoxycarbonyl)-L-ornithyl]amino}hexanoyl)amino]ethyl}carbamate (Example 106A) in 1 ml of dioxane at RT. After 4 h at RT, the reaction solution is concentrated in vacuo, coevaporated with dichloromethane several times and dried under high vacuum. The crude product is reacted without further purification.

후처리

  1. concentrationthe reaction solution is concentrated in vacuo
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

출처 및 근거

ORD 기록
ord-573c722c852946eab2101eaa90bcdd2b
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446102B2

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