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Hydrochloric Acid → Benzyl((5s)-7-[(3-amino-2-hydroxypropyl)amino]-5-{[(benzyloxy)carbonyl]amino}-7-oxoheptyl)carbamate hydrochloride

HRID 269656
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HRID 269656 반응식
[ClH:1].[CH2:2]([O:9][C:10](=[O:44])[NH:11][C@H:12]([CH2:28][C:29]([NH:31][CH2:32][CH:33]([OH:43])[CH2:34][NH:35]C(OC(C)(C)C)=O)=[O:30])[CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]([O:20]CC1C=CC=CC=1)=[O:19])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCOCC1>[ClH:1].[CH2:2]([N:17]([CH2:16][CH2:15][CH2:14][CH2:13][C@H:12]([NH:11][C:10]([O:9][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)=[O:44])[CH2:28][C:29]([NH:31][CH2:32][CH:33]([OH:43])[CH2:34][NH2:35])=[O:30])[C:18](=[O:19])[OH:20])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1
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참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 131727161benzyl{(1S)-5-{[(benzyloxy)carbonyl]amino}-1-[2-({3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]pentyl}carbamate

생성물 1

HCID 69219646Benzyl((5s)-7-[(3-amino-2-hydroxypropyl)amino]-5-{[(benzyloxy)carbonyl]amino}-7-oxoheptyl)carbamate hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

11 ml of a 4M solution of hydrogen chloride in dioxane are added to a solution of 160 mg (0.267 mmol) of benzyl{(1S)-5-{[(benzyloxy)carbonyl]amino}-1-[2-({3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]pentyl}carbamate (Example 160A) in 5.5 ml of dioxane at 0° C. The mixture is stirred at RT for 1 h. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum. The crude product is reacted without further purification.

후처리

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

출처 및 근거

ORD 기록
ord-3fc73e7a9e9c43728f173b23b7fc075e
출처 데이터셋
uspto-grants-2008_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07446102B2

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