Hydrochloric Acid → Benzyl((4S)-5-[(3-amino-2-hydroxypropyl)amino]-4-{[(benzyloxy)carbonyl]amino}-5-oxopentyl)carbamate hydrochloride

HRID 269688노트

반응식

HRID 269688 반응식
[ClH:1].[CH2:2]([O:9][C:10](=[O:42])[NH:11][C@H:12]([C:27]([NH:29][CH2:30][CH:31]([OH:41])[CH2:32][NH:33]C(OC(C)(C)C)=O)=[O:28])[CH2:13][CH2:14][CH2:15][NH:16][C:17]([O:19]CC1C=CC=CC=1)=[O:18])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCOCC1>[ClH:1].[CH2:2]([N:16]([CH2:15][CH2:14][CH2:13][C@H:12]([NH:11][C:10]([O:9][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)=[O:42])[C:27]([NH:29][CH2:30][CH:31]([OH:41])[CH2:32][NH2:33])=[O:28])[C:17](=[O:18])[OH:19])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86625290Benzyl {(1S)-4-{[(benzyloxy)carbonyl]amino}-1-[({3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}amino)carbonyl]butyl}carbamate

생성물 1

HCID 69219437Benzyl((4S)-5-[(3-amino-2-hydroxypropyl)amino]-4-{[(benzyloxy)carbonyl]amino}-5-oxopentyl)carbamate hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

6.8 ml of a 4N solution of hydrogen chloride in dioxane are added to a solution of 0.263 g (0.46 mmol) of the compound from Example 258A in 1 ml of dioxane at 0° C. After 2 h at RT, the reaction solution is concentrated in vacuo and coevaporated with dichloromethane several times. The remaining solid is dried to constant weight under high vacuum.

후처리

  1. concentrationthe reaction solution is concentrated in vacuo
  2. customThe remaining solid is dried to constant weight under high vacuum

출처 및 근거

ORD 기록
ord-3d01529a49944a54b455c638c2d93029
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446102B2

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