Hydrazine hydrate (1:1) → 1-(Pyridin-2-yl)piperidine-4-carbohydrazide

HRID 269734노트

반응식

HRID 269734 반응식
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:8][CH2:7]1)=O)C.O.[NH2:19][NH2:20]>CO>[N:9]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:10][CH2:11][CH:6]([C:4]([NH:19][NH2:20])=[O:3])[CH2:7][CH2:8]1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)2회HCID 38156184-Piperidinecarboxylic acid, 1-(2-pyridinyl)-, ethyl ester

생성물 1

HCID 235440481-(Pyridin-2-yl)piperidine-4-carbohydrazide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3,4,5,6-Tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid ethyl ester (35 g, 150 mmol) (see reference Farmaco, 1993, 48(10), 1439) was dissolved in methanol (700 mL) containing hydrazine hydrate (34 mL, 150 mmol) and was heated under reflux for 18 hours. After this time, more hydrazine hydrate (22.7 mL, 100 mmol) was added and the mixture stirred for a further 18 hours. The mixture was cooled to room temperature and evaporated under reduced pressure. The solid formed was triturated with ethyl acetate to give the title compound as a white solid.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. customevaporated under reduced pressure
  4. customThe solid formed
  5. customwas triturated with ethyl acetate

출처 및 근거

ORD 기록
ord-91b6afd42fe54328a546719c646703e3
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449462B2

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