2-Fluoro-4-nitrotoluene → 2-(4-Amino-2-fluorophenyl)ethanol

HRID 269804노트

반응식

HRID 269804 반응식
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[CH3:11].[CH3:12][O-:13].[Na+]>CS(C)=O>[F:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][OH:13])[NH2:8]

참가 물질

4

반응물 2

HCID 740252-Fluoro-4-nitrotolueneHCID 10942334Sodium Methoxide

생성물 1

HCID 450906002-(4-Amino-2-fluorophenyl)ethanol

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

2-Fluoro-4-nitrotoluene and p-formaldehyde were allowed to undergo the reaction in DMSO in the presence of sodium methoxide, and then the resulting compound was subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain 3-fluoro-4-(2-hydroxyethyl)aniline. F: 156.

출처 및 근거

ORD 기록
ord-a0076cd7d98346488810ae7fab1d0183
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449456B2

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