1-(4-Methoxyphenyl)-4-phenethylpiperazine → 4-[4-(3-Cyclohexylpropyl)piperidino]-2,5-difluorophenol

HRID 269912

반응식

HRID 269912 반응식
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1.[CH:23]1([CH2:29][CH2:30][CH2:31][CH:32]2[CH2:37][CH2:36][N:35]([C:38]3[CH:43]=[C:42]([F:44])[C:41]([O:45]C)=[CH:40][C:39]=3[F:47])[CH2:34][CH2:33]2)[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH:23]1([CH2:29][CH2:30][CH2:31][CH:32]2[CH2:37][CH2:36][N:35]([C:38]3[C:39]([F:47])=[CH:40][C:41]([OH:45])=[C:42]([F:44])[CH:43]=3)[CH2:34][CH2:33]2)[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1

참가 물질

3

반응물 2

HCID 155270761-(4-Methoxyphenyl)-4-phenethylpiperazineHCID 231114634-(3-Cyclohexylpropyl)-1-(2,5-difluoro-4-methoxyphenyl)piperidine

생성물 1

HCID 231114444-[4-(3-Cyclohexylpropyl)piperidino]-2,5-difluorophenol수율 253.6%

실험 절차

Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 4-(3-cyclohexylpropyl)-1-(2,5-difluoro-4-methoxyphenyl)piperidine (246 mg), to provide crude 4-[4-(3-cyclohexylpropyl)piperidino]-2,5-difluorophenol (599 mg).

출처 및 근거

ORD 기록
ord-df1ee3b037704b27a0d4791d3ad1df9b
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449466B2

연결된 노트

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