1-(2-Cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine → 4-[4-(2-Cyclohexylethyl)piperazin-1-yl]-2,5-difluorophenol

HRID 269924

반응식

HRID 269924 반응식
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1C.[CH:24]1([CH2:30][CH2:31][N:32]2[CH2:37][CH2:36][N:35]([C:38]3[CH:43]=[C:42]([F:44])[C:41]([O:45]C)=[CH:40][C:39]=3[F:47])[CH2:34][CH2:33]2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH:24]1([CH2:30][CH2:31][N:32]2[CH2:37][CH2:36][N:35]([C:38]3[C:39]([F:47])=[CH:40][C:41]([OH:45])=[C:42]([F:44])[CH:43]=3)[CH2:34][CH2:33]2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

참가 물질

3

반응물 2

HCID 231114791-(2-Cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazineHCID 231115101-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine

생성물 1

HCID 231114604-[4-(2-Cyclohexylethyl)piperazin-1-yl]-2,5-difluorophenol수율 36.3%

실험 절차

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(2-cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)-piperazine (250 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=13:1) to provide 4-[4-(2-cyclohexylethyl)piperazin-1-yl]-2,5-difluorophenol (87 mg).

후처리

  1. customThe resulting crude product was purified on TLC (developer, chloroform: methanol=13:1)

출처 및 근거

ORD 기록
ord-60e5a080e5344211a2f049a0081f27ba
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449466B2

연결된 노트

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