Isovaleryl chloride → 4-(2,5-Difluoro-4-methoxyphenyl)-1-(octylsulfonyl)piperazine

HRID 269942

반응식

Cl.Cl.COC1C=CC(N2CCNCC2)=CC=1.C(Cl)(=O)CC(C)C.[F:24][C:25]1[CH:30]=[C:29]([O:31][CH3:32])[C:28]([F:33])=[CH:27][C:26]=1[N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1.[CH2:40]([S:48](Cl)(=[O:50])=[O:49])[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH3:47]>>[F:24][C:25]1[CH:30]=[C:29]([O:31][CH3:32])[C:28]([F:33])=[CH:27][C:26]=1[N:34]1[CH2:39][CH2:38][N:37]([S:48]([CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])(=[O:50])=[O:49])[CH2:36][CH2:35]1

참가 물질

반응물 4

HCID 66054Isovaleryl chloride

HCID 822611-Octanesulfonyl chloride

HCID 27237001-(4-Methoxyphenyl)-piperazine, dihydrochloride

HCID 231114921-(2,5-Difluoro-4-methoxyphenyl)piperazine

생성물 1

HCID 231114774-(2,5-Difluoro-4-methoxyphenyl)-1-(octylsulfonyl)piperazine

실험 절차

Production Example 3 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and isovaleryl chloride were replaced with 1-(2,5-difluoro-4-methoxyphenyl)-piperazine (456 mg) and 1-octanesulfonyl chloride (470 μL), respectively, to provide crude 4-(2,5-difluoro-4-methoxyphenyl)-1-(octylsulfonyl)piperazine (681 mg).

출처 및 근거

ORD 기록: ord-990d7e1f09e3475ba7413660505d1012
출처 데이터셋: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07449466B2

연결된 노트

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