Ethyl 2-aminobenzoate → Ethyl 2-(1H-pyrrol-1-yl)benzoate

HRID 270004노트

반응식

HRID 270004 반응식
[CH2:1]([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH2:11])[CH3:2].CO[CH:15]1[CH2:19][CH2:18][CH:17](OC)O1>C(O)(=O)C>[CH2:1]([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH:15]=[CH:19][CH:18]=[CH:17]1)[CH3:2]

참가 물질

4

반응물 2

HCID 6877Ethyl 2-aminobenzoateHCID 790982,5-Dimethoxytetrahydrofuran

생성물 1

HCID 12673310Ethyl 2-(1H-pyrrol-1-yl)benzoate

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a stirred solution of 2-amino benzoic acid ethyl ester (20 g; 121 mmol) in acetic acid (35 mL) was added 2,5-dimethoxytetrahydrofuran (19 g; 174 mmol). The reaction mixture was stirred for two hours at reflux. After evaporation of the solvent, the crude product was purified by flash column chromatography (methylene chloride) to give compound 2-pyrrol-1-yl-benzoic acid ethyl ester as a yellow oil. Rf=0.63 (methylene chloride); (22.2 g; 103 mmol; 85%)

후처리

  1. temperatureat reflux
  2. customAfter evaporation of the solvent
  3. customthe crude product was purified by flash column chromatography (methylene chloride)

출처 및 근거

ORD 기록
ord-38830af035d44438b1b802bd7fffa03e
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449481B2

반응 노트

불러오는 중…