1-Benzyl-4-piperidone → HCID 67377897, 화합물

HRID 270051

반응식

HRID 270051 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]2([C:17]3[CH:18]=[C:19](Cl)[CH:20]=[CH:21][C:16]=3[C:15](=[O:23])[O:14]2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.BrC1C=CC([F:34])=CC=1C(O)=O.C(N1CCC(=O)CC1)C1C=CC=CC=1.C([Li])CCC>C1COCC1>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]2([C:17]3[CH:18]=[CH:19][C:20]([F:34])=[CH:21][C:16]=3[C:15](=[O:23])[O:14]2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 192201-Benzyl-4-piperidoneHCID 27781812-Bromo-5-fluorobenzoic acidHCID 12213047HCID 12213047, 화합물HCID 178418339Butyllithium

생성물 1

HCID 67377897HCID 67377897, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

This reaction was performed as described for (i) above using 2-bromo-5-fluorobenzoic acid (2.19 g, 10.0 mmol), 1-benzylpiperidin-4-one (3.78 g, 20.0 mmol), n-butyl lithium (n-BuLi) (20 mL) and THF (20 mL) to give the sub-titled compound.

출처 및 근거

ORD 기록
ord-6270015648f2484cb820595c68701494
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449475B2

연결된 노트

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