Methyl Salicylate → N-Methylsalicylamide

HRID 270101

반응식

HRID 270101 반응식
[C:1]([O:10]C)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[CH3:12][NH2:13]>CO>[OH:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]([NH:13][CH3:12])=[O:10]

참가 물질

4

반응물 2

HCID 4133Methyl SalicylateHCID 6329Methylamine

생성물 1

HCID 74624N-Methylsalicylamide수율 90.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of methyl salicylate (5.16 mL, 40 mmol) in methanol (10 mL) was added dropwise to aqueous 40% methylamine (18.1 mL, 210 mmol) at 0° C. After addition was complete the reaction mixture was kept on stirring at room temperature overnight. The volatiles were removed in vacuo to give the subtitled compound (5.48 g).

후처리

  1. additionAfter addition
  2. customThe volatiles were removed in vacuo

출처 및 근거

ORD 기록
ord-6df448f464b946efb1c50dd83b17c1f4
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449475B2

연결된 노트

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