Nitric Acid → 6-Nitrophthalide

HRID 27019

반응식

HRID 27019 반응식
[N+:1]([O-:4])(O)=[O:2].CN(C)C1C=C(N(C)C)C=CC=1[C:16]1(C2C=CC(N(C)C)=CC=2)[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:18](=[O:19])[O:17]1>S(=O)(=O)(O)O>[N+:1]([C:22]1[CH:21]=[C:20]2[C:25]([CH2:16][O:17][C:18]2=[O:19])=[CH:24][CH:23]=1)([O-:4])=[O:2]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 204408323-(2,4-Bis(dimethylamino)phenyl)-3-(4-(dimethylamino)phenyl)phthalide

생성물 1

HCID 2235846-Nitrophthalide

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매2회

실험 절차

Three portions of a mixture of concentrated nitric acid (0.6 ml. each portion) and concentrated sulfuric acid (0.66 ml. each portion) were added to a mixture of 3-(2,4-bis(dimethylamino)phenyl)-3-(4-(dimethylamino)phenyl)phthalide (4.17 g.) and concentrated sulfuric acid (20 ml.) with cooling. After each addition the temperature was allowed to rise to room temperature. The resulting mixture was poured onto ice and the resulting mixture was basified, affording 3-(2,4-bis(dimethylamino)phenyl)-3-(4-(dimethylamino)phenyl)-5 or 6-nitrophthalide (I: X=Y4 =(CH3)2N, Y2 =Z4 =Z7 =H, Z5 or Z6 =O2N and the other of Z5 or Z6 =H) or a mixture of both.

후처리

  1. temperaturewith cooling
  2. additionAfter each addition the temperature
  3. customto rise to room temperature
  4. additionThe resulting mixture was poured onto ice

출처 및 근거

ORD 기록
ord-13d623aa37214a3c893bc9d4a7946938
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04220357

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