Dimethylcarbamoyl Chloride → 1-(N,N-Dimethylcarbamoyl)-4,5-dicyanoimidazole

HRID 27032

반응식

HRID 27032 반응식
O1CCOCC1.[C:7]([C:9]1[N:10]=[CH:11][NH:12][C:13]=1[C:14]#[N:15])#[N:8].C(N(CC)CC)C.[CH3:23][N:24]([CH3:28])[C:25](Cl)=[O:26]>>[CH3:23][N:24]([CH3:28])[C:25]([N:10]1[C:9]([C:7]#[N:8])=[C:13]([C:14]#[N:15])[N:12]=[CH:11]1)=[O:26]

참가 물질

5

반응물 4

HCID 6598Dimethylcarbamoyl ChlorideHCID 8471TriethylamineHCID 312751,4-DioxaneHCID 707294,5-Dicyanoimidazole

생성물 1

HCID 233434181-(N,N-Dimethylcarbamoyl)-4,5-dicyanoimidazole

실험 절차

To 50 ml of dry 1,4-dioxane 6.0 g (0.05 mole) of 4,5-dicyanoimidazole, 5.0 g (0.05 mole) of triethylamine and 6.0 g (0.055 mole) of dimethylcarbamoyl chloride are added in succession at room temperature. This mixture is stirred and refluxed for 3 days, cooled to room temperature and evaporated to dryness. The residue is stirred in 50 ml of ethyl acetate and 50 ml water. The organic layer is separated, washed, dried and evaporated to give 8 g. (85%) of white product.

후처리

  1. temperaturerefluxed for 3 days
  2. customevaporated to dryness
  3. stirringThe residue is stirred in 50 ml of ethyl acetate
  4. customThe organic layer is separated
  5. washwashed
  6. customdried
  7. customevaporated
  8. customto give 8 g

출처 및 근거

ORD 기록
ord-ccbdcc529e104ca9a8cdaf4b5e1e4621
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04220466

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