Pyrrolidine → 3-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-propyl-pyrrolidine

반응식

Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]2[C:13]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)=[CH:12][S:11][C:10]=2[CH:21]=1.[NH:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1>>[F:20][C:17]1[CH:18]=[CH:19][C:14]([C:13]2[C:9]3[CH:8]=[CH:7][C:6]([O:5][CH2:4][CH2:3][CH2:2][N:22]4[CH2:26][CH2:25][CH2:24][CH2:23]4)=[CH:21][C:10]=3[S:11][CH:12]=2)=[CH:15][CH:16]=1

참가 물질

반응물 2

HCID 31268Pyrrolidine

HCID 223140346-(3-Bromo-propoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene

생성물 1

HCID 223140063-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-propyl-pyrrolidine

실험 절차

In analogy to example 3.1, 6-(3-Bromo-propoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene and pyrrolidine were converted to yield 1-{3-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-propyl}-pyrrolidine as colorless oil, MS: 356 (MH+).

출처 및 근거

ORD 기록: ord-d577cf0a7f83485988474211d21c444e
출처 데이터셋: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07449483B2

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