tert-Butyl 4-(trifluoromethyl)-3',6'-dihydro-2,4'-bipyridine-1'(2'H)-carboxylate → HCID 59833569, 화합물
반응식
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH:14]=2)[CH:4]=1>Cl.O1CCOCC1>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH:14]=2)[CH:4]=1참가 물질
4
실험 절차
tert-Butyl 4-(trifluoromethyl)-3′,6′-dihydro-2,4′-bipyridine-1′(2′H)-carboxylate (380.0 mg, 1.157 mmol) was dissolved in a 4 M solution of HCl in 1,4-dioxane (12.0 mL) to form a light yellow clear (then cloudy) solution. After being stirred at room temperature for 1 h, the reaction mixture was concentrated in vacuo to afford 389 mg of product as a yellow gum. LC-MS calculated for C11H11F3N2: (M+H) 229; found 229.1.
후처리
- customto form a light yellow clear (then cloudy) solution
- concentrationthe reaction mixture was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-af88db10ab1d405584d58ed2a7906fdf
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07449467B2
반응 노트
불러오는 중…