Hydrochloric Acid → (1R,3S)-3-[(3R)-tetrahydrofuran-3-yl]-3-(4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-ylcarbonyl)cyclopentanamine dihydrochloride

HRID 270617노트

반응식

HRID 270617 반응식
[O:1]1[CH2:5][CH2:4][C@H:3]([C@:6]2([C:19]([N:21]3[CH2:26][CH2:25][N:24]([C:27]4[CH:32]=[C:31]([C:33]([F:36])([F:35])[F:34])[CH:30]=[CH:29][N:28]=4)[CH2:23][CH2:22]3)=[O:20])[CH2:10][CH2:9][C@@H:8]([NH:11]C(=O)OC(C)(C)C)[CH2:7]2)[CH2:2]1.[ClH:37]>CCOCC>[ClH:37].[ClH:37].[O:1]1[CH2:5][CH2:4][C@H:3]([C@:6]2([C:19]([N:21]3[CH2:22][CH2:23][N:24]([C:27]4[CH:32]=[C:31]([C:33]([F:35])([F:34])[F:36])[CH:30]=[CH:29][N:28]=4)[CH2:25][CH2:26]3)=[O:20])[CH2:10][CH2:9][C@@H:8]([NH2:11])[CH2:7]2)[CH2:2]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86641538tert-Butyl [(1R,3S)-3-[(3R)-Tetrahydrofuran-3-yl]-3-(4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-ylcarbonyl)cyclopentyl]carbamate

생성물 1

HCID 68596876(1R,3S)-3-[(3R)-tetrahydrofuran-3-yl]-3-(4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-ylcarbonyl)cyclopentanamine dihydrochloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

tert-Butyl [(1R,3S)-3-[(3R)-tetrahydrofuran-3-yl]-3-(4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-ylcarbonyl)cyclopentyl]carbamate (260 mg, 0.51 mmol) was dissolved in a 2 M solution of of hydrogen chloride in ether (8 mL). After being stirred at room temperature overnight, the reaction mixture was concentrated under vacuum to provide the desired product (290 mg) as a light yellow solid. MS calculated for C20H27F3N4O2: (M+H) 413.2; found 413.0.

후처리

  1. concentrationthe reaction mixture was concentrated under vacuum

출처 및 근거

ORD 기록
ord-bf5585bb80584908bcfa2001427ab8dd
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449467B2

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