Methyl iodide → methyl N'-(4-cyanophenyl)carbamimidothioate

HRID 270623노트

반응식

HRID 270623 반응식
I[CH3:2].[C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([NH2:14])=[S:13])=[CH:7][CH:6]=1)#[N:4]>CC(C)=O>[C:3]([C:5]1[CH:6]=[CH:7][C:8]([N:11]=[C:12]([S:13][CH3:2])[NH2:14])=[CH:9][CH:10]=1)#[N:4]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 2757973(4-Cyanophenyl)thiourea

생성물 1

HCID 13748458methyl N'-(4-cyanophenyl)carbamimidothioate수율 84%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Iodomethane (1.76 ml) was added to 4-cyanophenyl-thiourea (5.0 g) in acetone (100 ml). The reaction mixture was stirred overnight at RT. The precipitate was filtered off, dried and dissolved in DCM. The organic solution was washed with NH3 (aq.) (excess), dried with potassium carbonate, filtered, and the solvent was evaporated, yielding 4.53 g (84%, white solid) of methyl N′-(4-cyanophenyl)-carbamimidothioate (intermediate 6).

후처리

  1. filtrationThe precipitate was filtered off
  2. customdried
  3. dissolutiondissolved in DCM
  4. washThe organic solution was washed with NH3 (aq.) (excess)
  5. dry with materialdried with potassium carbonate
  6. filtrationfiltered
  7. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-cc177943ede343319750c72a1105e24b
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449575B2

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