Ticlopidine → 4,5,6,7-Tetrahydrothieno(3,2-c)pyridine

반응식

C1C=CC(Cl)=C(C[N:8]2[CH2:16][C:12]3[CH:13]=[CH:14][S:15][C:11]=3[CH2:10][CH2:9]2)C=1.NCCC1SC=CC=1>>[S:15]1[C:11]2[CH2:10][CH2:9][NH:8][CH2:16][C:12]=2[CH:13]=[CH:14]1

참가 물질

반응물 2

HCID 5472Ticlopidine

HCID 116521Thiopheneethanamine

생성물 1

HCID 30850764,5,6,7-Tetrahydrothieno(3,2-c)pyridine

실험 절차

Alternatively, ticlopidine of formula (1a) may also be synthesized by directly cyclizing 2-(2-aminoethyl)thiophene of formula (a) with a formylating agent to obtain 4,5,6,7-tetrahydrothieno[3,2-c]pyridine of formula (f), and then reacting the compound (f) with a compound of formula (b).

출처 및 근거

ORD 기록: ord-8918957f0be54d69b3276552a895d2b6
출처 데이터셋: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07449580B2

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