Dimethylformamide → HCID 178434610, 화합물

HRID 270786

반응식

HRID 270786 반응식
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([F:10])([F:9])[F:8])[NH:4][N:3]=1.CN(C=O)C.[Cl:16]N1C(=O)CCC1=O>O>[Cl:16][C:6]1[C:2]([CH3:1])=[N:3][NH:4][C:5]=1[C:7]([F:10])([F:9])[F:8]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 31398ChlorosuccinimideHCID 1390771H-Pyrazole, 3-methyl-5-(trifluoromethyl)-

생성물 1

HCID 178434610HCID 178434610, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

3-methyl-5-trifluoromethylpyrazole was taken into dry DMF (20 mL) and N-chloro succinimide (1.78 g) was added in portions. The mixture was then heated at 70° C. for 22 h, cooled to room temperature, and then water (100 mL) was added and the mixture extracted with ethyl acetate (4×25 mL). The organic layer was washed with water and brine and dried with Na2SO4. Evaporation of the solvent afforded the title compound.

후처리

  1. additionwas added in portions
  2. temperaturecooled to room temperature
  3. extractionthe mixture extracted with ethyl acetate (4×25 mL)
  4. washThe organic layer was washed with water and brine
  5. dry with materialdried with Na2SO4
  6. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-54f8eead3ef64bd1b4ef90c1484c3d55
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449576B1

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