참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Butyl isocyanate | HCID 8110 | — |
| 반응물 | 6-(furan-2-yl)-9H-purin-2-amine | HCID 178508247 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Amino-N-n-butyl-6-(2-furyl)-9H-purine-9-carboxamide | HCID 9944151 | 100% |
반응 단계
A solution of 6-(2-furyl)-1H-purine-2-amine (0.050 g, 0.25 mmol) and DMAP (5 mg, 0.03 mmol) in anhydrous DMF (1 μL) was treated with n-butylisocyanate (0.029 g, 0.30 mmol), shaken at 65° C. for 1 h, poured onto ice-cold water (10 mL), cooled at 0° C. for 15 min and the resulting precipitate filtered and dried in vacuo over P2O5 to give the title compound (74 mg, 100%) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07452894B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_11 |
|---|
| ORD ID | ord-692e9921ab9a4a878d1a098fd1e3fa5d |
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| 출처 메모 | uspto-grants-2008_11 |
|---|
