Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl Acrylate → Methyl 3-(2-amino-6-(2-furyl)-9H-purine-9-yl)propionate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl Acrylate | HCID 7294 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 6-(furan-2-yl)-9H-purin-2-amine | HCID 178508247 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Methyl 3-(2-amino-6-(2-furyl)-9H-purine-9-yl)propionate | HCID 59834959 | 11.4% |
반응 단계
A solution of 6-(2-furyl)-1H-purine-2-amine (0.70 g, 3.48 mmol) and K2CO3 (0.48 g, 3.48 mmol) in DMF (20 mL) was treated with methyl acrylate (3.3 g, 38.3 mmol), stirred for 40 h, diluted with EtOAc, filtered to remove polymeric acrylate, washed with water, dried (MgSO4), concentrated in vacuo and purified by chromatography [SiO2: EtOAc-heptane, (4:1)] to give the title compound (114 mg, 11%) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07452894B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-3c35fbd01a794b259e7c22e35a4be0c5 |
| 출처 메모 | uspto-grants-2008_11 |