Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 178472544, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| 반응물 | (2S)-2-amino-3-[4-(4-methyl-1,3-dioxo-1,3-dihydroisoindole-2-yl)phenyl]propionic acid ethylester hydrochloride | HCID 66960581 | — |
| 반응물 | HCID 178524540 | HCID 178524540 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | HCID 178472544 | HCID 178472544 | — |
반응 단계
The mixture of 35 mg of 2,6-dichloro-4-tetrazolyl benzoic acid, 30 mg of 1-(3-dimehtylaminopropyl)-3-ethylcarbodiimide hydrochloride, 23 mg of 1-hydroxybenzotriazol hydrate, 15 mg of triethylamine, 35 mg of (2S) -2-amino-3-[4-(4-methyl-1,3-dioxo-1,3-dihydroisoindole-2-yl)phenyl] propionic acid ethylester hydrochloride and 5 ml of dichloromethane was stirred at room temperature for 3 days. The mixture was concentrated and suspended in a mixed solvent of water-acetonitrile containing 0.1% trifluoroacetic acid and then filtered to obtain the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07452905B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-ec2c917342434234b56c3b2e3fc22345 |
| 출처 메모 | uspto-grants-2008_11 |