Hydrochloric Acid → HCID 17968237, 화합물

HRID 271574노트

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HRID 271574 반응식
[CH3:1][C:2]([CH3:30])([CH3:29])[CH2:3][N:4]1[C:8]2[N:9]=[C:10]([C:13]#[N:14])[N:11]=[CH:12][C:7]=2[CH:6]=[C:5]1[CH2:15][N:16]1[CH2:21][CH2:20][N:19]([C:22]2[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=2)[CH2:18][CH2:17]1.[CH3:31][N:32]([CH2:34][CH3:35])[CH3:33].Cl.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:31][N:32]([CH3:33])[CH2:34][CH2:35][O:28][C:25]1[CH:24]=[CH:23][C:22]([N:19]2[CH2:18][CH2:17][N:16]([CH2:15][C:5]3[N:4]([CH2:3][C:2]([CH3:30])([CH3:29])[CH3:1])[C:8]4[N:9]=[C:10]([C:13]#[N:14])[N:11]=[CH:12][C:7]=4[CH:6]=3)[CH2:21][CH2:20]2)=[CH:27][CH:26]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 11723DimethylethylamineHCID 17968218HCID 17968218, 화합물

생성물 1

HCID 17968237HCID 17968237, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

0.24 g 7-(2,2-dimethyl-propyl)-6-[4-(4-hydroxy-phenyl)-piperazin-1-ylmethyl]-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile and 0.128 g dimethylaminoethane.HCl were stirred in 2 ml of acetone in the presence of 0.41 g of potassium carbonate. After 18 hours the mixture was extracted with ethyl acetate/water, dried over Magnesium sulfate and evaporated. The residue was chromatographed on silicagel using CH2Cl2/MeOH yielding 6-{4-[4-(2-dimethylamino-ethoxy)-phenyl]-piperazin-1-ylmethyl}-7-(2,2-dimethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile as colorless wax.

후처리

  1. extractionAfter 18 hours the mixture was extracted with ethyl acetate/water
  2. dry with materialdried over Magnesium sulfate
  3. customevaporated
  4. customThe residue was chromatographed on silicagel

출처 및 근거

ORD 기록
ord-8cdfb2b79c6c48318efe840a73a2d391
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07452886B2

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