Cyclohexyl phenyl ketone → Cyclohexyl-phenyl-methanone oxime

HRID 271838

반응식

HRID 271838 반응식
Cl.[NH2:2][OH:3].C([O-])(=O)C.[Na+].[CH:9]1([C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>CO>[CH:9]1([C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:2][OH:3])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

참가 물질

5

반응물 3

HCID 12837Cyclohexyl phenyl ketoneHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 346900Cyclohexyl-phenyl-methanone oxime

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Hydroxylamine hydrochloride (0.48 g, 6.7 mMol) and sodium acetate (1.4 g, 10.2 mMol) were added to a round bottom flask containing cyclohexyl-phenyl-methanone Compound 18a (0.97 g, 5.1 mMol) in MeOH (30 mL) at r.t. The mixture was stirred at r.t. for 15 hrs. The solvent was removed in vacuo and the residue was extracted with CH2Cl2. The organic layer was sequentially washed with a saturated solution of NaHCO3, then brine. The organic layer was dried over Na2SO4, decanted and the solvent removed in vacuo to provide cyclohexyl-phenyl-methanone oxime Compound 18b (1.0 g) as a white solid, which was used in the next step without purification. MS m/z 204 (MH+).

후처리

  1. customThe solvent was removed in vacuo
  2. extractionthe residue was extracted with CH2Cl2
  3. washThe organic layer was sequentially washed with a saturated solution of NaHCO3
  4. dry with materialThe organic layer was dried over Na2SO4
  5. customdecanted
  6. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-83d6825bf7914461b78e20bc77d4d6a9
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07452997B2

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