2-[(Thiazol-2-yl)methylthio]ethylamine → 3-[2-(2-Thiazolylmethylthio)ethylamino]-6-(3-methoxybenzyl)-1,2,4-triazin-5-one

HRID 27217

반응식

HRID 27217 반응식
CS[C:3]1[NH:8][C:7](=[O:9])[C:6]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)=[N:5][N:4]=1.[S:19]1[CH:23]=[CH:22][N:21]=[C:20]1[CH2:24][S:25][CH2:26][CH2:27][NH2:28]>>[S:19]1[CH:23]=[CH:22][N:21]=[C:20]1[CH2:24][S:25][CH2:26][CH2:27][NH:28][C:3]1[NH:8][C:7](=[O:9])[C:6]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)=[N:5][N:4]=1

참가 물질

3

반응물 2

HCID 129234032-[(Thiazol-2-yl)methylthio]ethylamineHCID 1356242923-Methylthio-6-(3-methoxybenzyl)-1,2,4-triazin-5-one

생성물 1

HCID 1357032243-[2-(2-Thiazolylmethylthio)ethylamino]-6-(3-methoxybenzyl)-1,2,4-triazin-5-one수율 47.6%

실험 절차

3-Methylthio-6-(3-methoxybenzyl)-1,2,4-triazin-5-one (1.18 g) and 2-(2-thiazolylmethylthio)ethylamine (0.87 g) were heated together on an oil bath (160°-70°) for 3/4 hour. The resulting oil, after chromatography and crystallisation from ethanol, gave the title compound as a colourless solid (0.83 g) m.p. 128°-29°.

후처리

  1. customThe resulting oil, after chromatography and crystallisation from ethanol

출처 및 근거

ORD 기록
ord-91e47578093249e3a13d72b35c15fd5b
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04220767

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