Ethanol → HCID 178507684, 화합물

HRID 27224

반응식

HRID 27224 반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[C:4]([Cl:9])[N:3]=1.C([OH:12])C.ClC1C=CC=C(C(OO)=O)C=1.[OH-].[Na+]>O>[NH2:1][C:2]1[N+:7]([O-:12])=[C:6]([NH2:8])[CH:5]=[C:4]([Cl:9])[N:3]=1

참가 물질

6

반응물 4

HCID 702Ethanol2회HCID 14798Sodium HydroxideHCID 674322,4-Diamino-6-chloropyrimidineHCID 70297m-Chloroperbenzoic acid

생성물 1

HCID 178507684HCID 178507684, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
-10 °C

실험 절차

75 g. of 2,4-diamino-6-chloropyrimidine are dissolved in 1500 ml. of ethanol at 35° C. The solution is cooled to -10° C. and a solution of 100 g. of 3-chloro-perbenzoic acid in 500 ml. of ethanol is slowly added dropwise in the course of 1 hour. The suspension is subsequently stirred at -10° C. for 7 hours and left to stand at 5° C. overnight. The suspension is neutralized with 24 g. of sodium hydroxide in 100 ml. of water. The solid material is filtered off and recrystallized from ethanol, there being obtained pure 2,4-diamino-6-chloropyrimidine-3-oxide.

후처리

  1. customat 35° C
  2. waitleft
  3. waitto stand at 5° C. overnight
  4. filtrationThe solid material is filtered off
  5. customrecrystallized from ethanol, there

출처 및 근거

ORD 기록
ord-0cbe754051c04555a9debb952b65163a
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04220772

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