1,2,3,6-Tetrahydropyridine → HCID 178501988, 화합물

HRID 27227

반응식

HRID 27227 반응식
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]([O:11][CH3:12])=[O:10])[N+:5]([O-:13])=[C:4]([NH:14][C:15]([O:17][CH3:18])=[O:16])[CH:3]=1.[NH:19]1[CH2:24][CH2:23][CH:22]=[CH:21][CH2:20]1>C(Cl)Cl>[N:19]1([C:2]2[N:7]=[C:6]([NH:8][C:9]([O:11][CH3:12])=[O:10])[N+:5]([O-:13])=[C:4]([NH:14][C:15]([O:17][CH3:18])=[O:16])[CH:3]=2)[CH2:20][CH:21]=[CH:22][CH2:23][CH2:24]1

참가 물질

4

반응물 2

HCID 127501,2,3,6-TetrahydropyridineHCID 178501976HCID 178501976, 화합물

생성물 1

HCID 178501988HCID 178501988, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A suspension of 10 g. of dimethyl 6-chloro-2,4-pyrimidinedicarbamate-3-oxide in 40 ml. of methylene chloride is treated with 20 ml. of 1,2,5,6-tetrahydropyridine and stirred at room temperature under an argon atmosphere for 16 hours. The precipitate formed is filtered off and recrystallized from a mixture of methylene chloride and methanol, there being obtained pure dimethyl 6-[3,6-dihydro-1(2H)-pyridyl]-2,4-pyrimidinedicarbamate-3-oxide having a melting point of 203° C.

후처리

  1. additionA suspension of 10 g
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. customrecrystallized from a mixture of methylene chloride and methanol, there

출처 및 근거

ORD 기록
ord-12bf4e584d814a6e9a291da96b9af07e
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04220772

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