Methyl iodide → HCID 45119279, 화합물

HRID 272536

반응식

HRID 272536 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:4][N:3]=1.[OH-].[K+].[CH3:14]I>CC(C)=O>[Cl:1][C:2]1[CH:7]=[C:6]([N:8]([CH3:14])[C:9](=[O:11])[CH3:10])[CH:5]=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 2049955N-(2-chloropyridin-4-yl)acetamide

생성물 1

HCID 45119279HCID 45119279, 화합물수율 600.9%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 10 g (59 mmol) N-(2-chloropyridin-4-yl)acetamide (commercially available), 9.8 g (17.6 mmol) pulverized KOH and 4.1 ml (6.4 mmol) methyl iodide in 60 ml acetone was stirred at room temperature for 2 h. After evaporation of all volatiles the residue was taken up in water and extracted with ethyl acetate. The combined organic layers were dried with MgSO4 and evaporated to yield 7.1 g (66%) of the title compound as off-white solid. MS: (m/e): 345.2 (MH+).

후처리

  1. customAfter evaporation of all volatiles the residue
  2. extractionextracted with ethyl acetate
  3. dry with materialThe combined organic layers were dried with MgSO4
  4. customevaporated

출처 및 근거

ORD 기록
ord-52ac5c96003c4f889411ab8a90617c22
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07456175B2

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