Lithium Hydroxide → Acetic acid 4-(3-iodo-pyrrolo[2,3-c]pyridin-1-ylmethyl)-phenyl ester

HRID 272767

반응식

HRID 272767 반응식
ClCC1C=CC(OC(=O)C)=CC=1.C(Br)C1C=CC=CC=1.[I:21][C:22]1[C:30]2[C:25](=[CH:26][N:27]=[CH:28][CH:29]=2)[N:24]([CH2:31][C:32]2[CH:37]=[CH:36][C:35]([O:38][C:39](=[O:41])[CH3:40])=[CH:34][CH:33]=2)[CH:23]=1.[Li+].[OH-]>C1COCC1.O>[I:21][C:22]1[C:30]2[C:25](=[CH:26][N:27]=[CH:28][CH:29]=2)[N:24]([CH2:31][C:32]2[CH:33]=[CH:34][C:35]([O:38][C:39](=[O:41])[CH3:40])=[CH:36][CH:37]=2)[CH:23]=1.[I:21][C:22]1[C:30]2[C:25](=[CH:26][N:27]=[CH:28][CH:29]=2)[N:24]([CH2:31][C:32]2[CH:37]=[CH:36][C:35]([OH:38])=[CH:34][CH:33]=2)[CH:23]=1

참가 물질

8

반응물 4

HCID 3939Lithium HydroxideHCID 7498Benzyl BromideHCID 1483124-(Chloromethyl)phenyl acetateHCID 69217841Acetic acid 4-(3-iodo-pyrrolo[2,3-c]pyridin-1-ylmethyl)-phenyl ester

생성물 2

HCID 69217841Acetic acid 4-(3-iodo-pyrrolo[2,3-c]pyridin-1-ylmethyl)-phenyl esterHCID 692187224-(3-Iodo-pyrrolo[2,3-c]pyridin-1-ylmethyl)-phenol

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

Acetic acid 4-(3-iodo-pyrrolo[2,3-c]pyridin-1-ylmethyl)-phenyl ester was prepared by substituting acetic acid 4-chloromethyl-phenyl ester and Example 717A for benzyl bromide and Example 695J, respectively, in Example 696A. Acetic acid 4-(3-iodo-pyrrolo[2,3-c]pyridin-1-ylmethyl)-phenyl ester was then slurried in a mixture of THF and water, and treated with LiOH to provide the desired product. MS (ESI) m/e 351 (M+H)+, 1H NMR (300 MHz, DMSO-d6): □ 9.44 (s, 1H), 8.87 (s, 1H), 8.20 (d, J=5.43 Hz, 1H), 7.93 (s, 1H), 7.24 (dd, J=5.43, 1.02 Hz, 1H), 7.18 (d, J=8.48 Hz, 2H), 6.68-6.72 (m, 2H), 5.40 (s, 2H).

출처 및 근거

ORD 기록
ord-6884e84bb4924fb297cbb938dafc6d1d
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07456169B2

연결된 노트

불러오는 중…