Thionyl Chloride → 3-Ethylcyclobutanecarboxylic acid chloride

반응식

[CH2:1]([CH:3]1[CH2:6][CH:5]([C:7]([OH:9])=O)[CH2:4]1)[CH3:2].S(Cl)([Cl:12])=O>>[CH2:1]([CH:3]1[CH2:6][CH:5]([C:7]([Cl:12])=[O:9])[CH2:4]1)[CH3:2]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 47796Cyclobutanecarboxylic acid, 3-ethyl-

생성물 1

HCID 450812713-Ethylcyclobutanecarboxylic acid chloride수율 60.6%

실험 절차

A mixture of 3.3 g (0.027 mole) of 3-ethylcyclobutanecarboxylic acid (prepared in 1E) and 9.4 g (5.7 ml, 0.080 mole) of thionyl chloride was prepared and allowed to stir at room temperature for about 15 hr. Excess thionyl chloride was removed by distillation at atmospheric pressure. The residue was distilled at reduced pressure to yield 2.4 g of the title compound having the following physical characteristics:

후처리

customwas prepared
customExcess thionyl chloride was removed by distillation at atmospheric pressure
distillationThe residue was distilled at reduced pressure

출처 및 근거

ORD 기록: ord-bd5aa059603b4de884c3fae56ebe28c3
출처 데이터셋: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04220795

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