Sodium Carbonate → 4-Pyrimidinecarboxylic acid

HRID 273106

반응식

HRID 273106 반응식
C[N:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH2:3]1.[Mn]([O-])(=O)(=O)=O.[K+].[C:14](=O)([O-:16])[O-:15].[Na+].[Na+]>O>[N:2]1[CH:7]=[CH:6][C:5]([C:14]([OH:16])=[O:15])=[N:4][CH:3]=1

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 516875Potassium PermanganateHCID 18974088HCID 18974088, 화합물

생성물 1

HCID 1693064-Pyrimidinecarboxylic acid수율 11%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

3-Methyl-pyrimidine (9.41 g, 100 mmol), potassium permanganate (26.9 g) and sodium carbonate (10.6 g) was refluxed in water (100 ml) for 72 h followed by filtration through celite. The filtrate was washed with several portions of DCM and EtOAc before acidification with conc. HCl. The formed precipitate was collected and washed with water to yield 1.37 g of the title compound as a white solid. 1H NMR (DMSO-d6) d (ppm): 13.94 (br. s, 1H), 9.37 (d, 1H), 9.07 (d, 1H), 8.01 (dd, 1H).

후처리

  1. filtrationfollowed by filtration through celite
  2. washThe filtrate was washed with several portions of DCM and EtOAc before acidification with conc. HCl
  3. customThe formed precipitate was collected
  4. washwashed with water

출처 및 근거

ORD 기록
ord-7cd744ccbfd14663aeb0ea21b33c2f20
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07456200B2

연결된 노트

불러오는 중…