Ethyl 3-(nitromethyl)heptanoate → 4-Butylpyrrolidin-2-one
반응식
C([O:3][C:4](=O)[CH2:5][CH:6]([CH2:11][N+:12]([O-])=O)[CH2:7][CH2:8][CH2:9][CH3:10])C.[H][H]>CO.[Ni]>[CH2:7]([CH:6]1[CH2:11][NH:12][C:4](=[O:3])[CH2:5]1)[CH2:8][CH2:9][CH3:10]참가 물질
5
실험 절차
To a solution of 3-nitromethylheptanoic acid ethyl ester (10 g, 49.2 mmol) in methanol (100 mL) under argon was added Raney Ni (5 g). The mixture was stirred under 50 psi of hydrogen for 48 h, flushed with argon, filtered through a Celite pad, and concentrated under vacuum to afford 4-butylpyrrolidin-2-one as a colorless oil (6.3 g, 91%). MS(ES) m/e 142 [M+H]+.
후처리
- customflushed with argon
- filtrationfiltered through a Celite pad
- concentrationconcentrated under vacuum
출처 및 근거
- ORD 기록
- ord-374e99d513034b30adb95a0386b6fa3f
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07456211B2
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