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Iodoethane → 5-(4-chlorophenyl)-N-ethyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide

HRID 273551
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HRID 273551 반응식
CCI.CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(Cl)cc4)o3)cc2)CC1>O=S(=O)(O)O.[Li]N([Si](C)(C)C)[Si](C)(C)C.CN(C)C=O.CN(C)C=O.CN(C)C=O.COCCOCCOC>CCN(C(=O)c1ccc(-c2ccc(Cl)cc2)o1)c1ccc(N2CCNCC2)cc1.CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(Cl)cc4)o3)cc2)CC1.CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(Cl)cc4)o3)cc2)CC1
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참가 물질

8

반응물 2

HCID 6340IodoethaneHCID 168301698t-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylate

생성물 2

HCID 706958985-(4-chlorophenyl)-N-ethyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide수율 22%HCID 168301698t-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylate2회

시약·촉매·용매 4

HCID 1118Sulfuric Acid시약HCID 178418261HCID 178418261, 화합물시약HCID 6228Dimethylformamide용매3회HCID 8150Diglyme용매

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온도
23 °C

후처리

  1. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  2. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  3. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  4. additionThe reactions were further diluted to 10 mM using DMSO.

출처 및 근거

ORD 기록
ord-a8aeb3c81c564ce9ad51570820b2cb2f
출처 데이터셋
Cernak miniaturized N-alkylation with BOC deprotection
DOI
10.1038/s44160-023-00351-1
원본 링크
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