Methyl iodide → 5-(4-cyanophenyl)-N-methyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide

HRID 273595노트

반응식

HRID 273595 반응식
CI.CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(C#N)cc4)o3)cc2)CC1>O=S(=O)(O)O.[Li]N([Si](C)(C)C)[Si](C)(C)C.CN(C)C=O.CN(C)C=O.CN(C)C=O.COCCOCCOC>CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(C#N)cc4)o3)cc2)CC1.CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(C#N)cc4)o3)cc2)CC1.CN(C(=O)c1ccc(-c2ccc(C#N)cc2)o1)c1ccc(N2CCNCC2)cc1

참가 물질

8

반응물 2

HCID 6328Methyl iodideHCID 168301699Tert-butyl 4-(4-(5-(4-cyanophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylate

생성물 2

HCID 168301699Tert-butyl 4-(4-(5-(4-cyanophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylate2회HCID 1683017105-(4-cyanophenyl)-N-methyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide수율 60%

시약·촉매·용매 4

HCID 1118Sulfuric Acid시약HCID 178418261HCID 178418261, 화합물시약HCID 6228Dimethylformamide용매3회HCID 8150Diglyme용매

반응 조건

온도
23 °C

후처리

  1. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  2. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  3. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  4. additionThe reactions were further diluted to 10 mM using DMSO.

출처 및 근거

ORD 기록
ord-170ec348e6a64bd6901d383a907e3bf8
출처 데이터셋
Cernak miniaturized N-alkylation with BOC deprotection
원본 링크
출처 보기

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